Symbol
Name
ID

Il15
interleukin 15
MGI:103014

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Autoimmunity	Asthma
Disease(s) Associated with IL15	Autoimmunity	Asthma
asthma
type 1 diabetes mellitus

Mouse Phenotypes

immune system phenotype

absent uterine NK cells

abnormal thymus cell ratio

enlarged spleen

abnormal CD8-positive, alpha-beta T cell differentiation

decreased dendritic cell number

decreased NK cell number

increased NK cell number

abnormal T cell subpopulation ratio

decreased CD8-positive, alpha-beta T cell number

abnormal NK T cell number

decreased NK T cell number

decreased CD8-positive, gamma-delta intraepithelial T cell number

decreased memory T cell number

increased memory T cell number

decreased regulatory T cell number

increased lymphocyte cell number

abnormal lymphocyte morphology

abnormal T cell morphology

increased spleen white pulp amount

abnormal lymphocyte physiology

decreased IgG level

decreased IgM level

decreased immunoglobulin level

impaired natural killer cell mediated cytotoxicity

abnormal CD8-positive, alpha-beta T cell physiology

increased circulating interleukin-15 level

abnormal interleukin level

abnormal immune system morphology

enlarged lymph nodes

small lymph nodes

abnormal immune system physiology

abnormal dendritic cell physiology

decreased susceptibility to type IV hypersensitivity reaction

abnormal cytokine secretion

decreased interferon-gamma secretion

abnormal interleukin secretion

decreased interleukin-12 secretion

abnormal inflammatory response

dermatitis

abnormal susceptibility to infection

decreased susceptibility to bacterial infection induced morbidity/mortality

increased susceptibility to Herpesvirales infection induced morbidity/mortality

increased susceptibility to Poxviridae infection induced morbidity/mortality

increased susceptibility to parasitic infection

Availability

Mouse Genotype

Il15^m1Hwata/Il15^m1Hwata

Il15^tm1Imx/Il15^tm1Imx

Il15^tm1.1Iku/Il15⁺

Tg(ACTA1-Il15)10941Lsq/0

Tg(ACTA1-Il15*)11650Lsq/0

Tg(H2-D-Il15)3304Clgr/?

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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